Tetrahedron

The rapid preparation of 2-aminosulfonamide-1, 3, 4-oxadiazoles using polymer-supported reagents and microwave heating

IR Baxendale, SV Ley, M Martinelli

Index: Baxendale, Ian R.; Ley, Steven V.; Martinelli, Marisa Tetrahedron, 2005 , vol. 61, # 22 p. 5323 - 5349

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Citation Number: 114

Abstract

Herein, we report on the preparation of a library of 5-substituted-2-amino-1, 3, 4-oxadiazoles and the corresponding thiadiazole analogues. Presented is a one-pot preparation of the 2- aminosulfonylated analogues through a three component coupling of an acylhydrazine, an isocyanate and sulfonyl chloride promoted by a polymer-supported phosphazine base under microwave dielectric heating. Also described is the optimization process and details ...