Tetrahedron letters

A mild, one-pot synthesis of disubstituted benzimidazoles from 2-nitroanilines

…, GM Adjabeng, HD Dickson, RG Davis-Ward

Index: Hornberger, Keith R.; Adjabeng, George M.; Dickson, Hamilton D.; Davis-Ward, Ronda G. Tetrahedron Letters, 2006 , vol. 47, # 30 p. 5359 - 5361

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Citation Number: 39

Abstract

A one-pot synthesis of disubstituted benzimidazoles from 2-nitroanilines is described. Hydrogenation of N-substituted 2-nitroanilines with palladium on carbon as catalyst in the presence of trimethyl orthoformate and catalytic pyridinium p-toluenesulfonate (PPTS) at room temperature provided good to excellent yields of the corresponding disubstituted benzimidazoles.

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