Synthesis of 1??Substituted Benzimidazoles from o??Bromophenyl Isocyanide and Amines

AV Lygin, A de Meijere

Index: Lygin, Alexander V.; De Meijere, Armin European Journal of Organic Chemistry, 2009 , # 30 p. 5138 - 5141

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Citation Number: 19

Abstract

Abstract o-Bromophenyl isocyanide (1-Br) reacts with various primary amines under Cu I catalysis to afford 1-substituted benzimidazoles 4 in moderate to good yields (38–70%, 13 examples). Analogously, 2-bromo-3-isocyanothiophene (6) furnishes 3-substituted 3H- thieno [2, 3-d] imidazoles 7 (44–49%, 3 examples).(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

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