Tetrahedron Letters

Synthesis of novel pentacyclic pyrrolothiazolobenzoquinolinones, analogs of natural marine alkaloids

V Bénéteau, T Besson

Index: Beneteau, Valerie; Besson, Thierry Tetrahedron Letters, 2001 , vol. 42, # 14 p. 2673 - 2676

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Citation Number: 29

Abstract

Multistep synthesis (12 steps) of new pentacyclic compounds, which are structurally very close to natural marine alkaloids, was performed via a Diels–Alder reaction between 4- methylene-5-(bromomethylene)-4, 5-dihydrothiazole and a protected dioxotryptamine, itself obtained from the commercially available 2, 5-dimethoxybenzaldehyde.