Organic letters

Transition-metal-free synthesis of benzimidazoles mediated by KOH/DMSO

H Baars, A Beyer, SV Kohlhepp, C Bolm

Index: Baars, Hannah; Beyer, Astrid; Kohlhepp, Stefanie V.; Bolm, Carsten Organic Letters, 2014 , vol. 16, # 2 p. 536 - 539

Full Text: HTML

Citation Number: 31

Abstract

Benzimidazoles can reveal important bioactivities,(4) and several strategies for their synthesis have been developed. Commonly, they are prepared from 1,2-diaminoarenes by condensations with carboxylic acids under harsh dehydrating conditions(5) or oxidative couplings with aldehydes.(6) Under milder reaction conditions benzimidazoles can be accessed from amidines by metal-catalyzed intramolecular C–N cross-couplings.(7) Considering our previous ...

Related Articles:

Cu-Catalyzed Aerobic Oxidation of Di-tert-butyl Hydrazodicarboxylate to Di-tert-butyl Azodicarboxylate and Its Application on Dehydrogenation of 1, 2, 3, 4- …

[Jin, Xukang; Liu, Yuxiao; Lu, Qiongqiong; Yang, Dejun; Sun, Jiangkai; Qin, Shuangshuang; Zhang, Jingwu; Shen, Jiaxuan; Chu, Changhu; Liu, Renhua Organic and Biomolecular Chemistry, 2013 , vol. 11, # 23 p. 3776 - 3780]

Cu-Catalyzed Aerobic Oxidation of Di-tert-butyl Hydrazodicarboxylate to Di-tert-butyl Azodicarboxylate and Its Application on Dehydrogenation of 1, 2, 3, 4- …

[Jin, Xukang; Liu, Yuxiao; Lu, Qiongqiong; Yang, Dejun; Sun, Jiangkai; Qin, Shuangshuang; Zhang, Jingwu; Shen, Jiaxuan; Chu, Changhu; Liu, Renhua Organic and Biomolecular Chemistry, 2013 , vol. 11, # 23 p. 3776 - 3780]

More Articles...