Search of antimycobacterial activities in hybrid molecules with benzopyran skeleton

…, SK Pandey, S Singh, SK Sinha, V Chaturvedi

Index: Tripathi, Rama P.; Bisht, Surendra Singh; Pandey, Vivek Parashar; Pandey, Sarvesh K.; Singh, Shubhra; Sinha, Sudhir Kumar; Chaturvedi, Vinita Medicinal Chemistry Research, 2011 , vol. 20, # 9 p. 1515 - 1522

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Citation Number: 9

Abstract

Abstract A series of hybrid molecules (7–9, 12, 13, and 14–18) consisting of chromans and pyrolidines or cyclic amines were prepared either by (3+ 2) cycloaddition of nitrostyrenes and azomethine ylide or by three component reactions of chromanyl aldehydes, acetylenes, and cyclic amines. All the synthesized compounds were evaluated against both avirulent (H37Ra) and virulent (H37Rv) strains of Mycobacterium tuberculosis. Out of all the ...

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