Journal of the American Chemical Society

Reactions of nitroimidazoles. Nucleophilic substitution of the nitro group

P Goldman, JD Wuest

Index: Goldman, P.; Wuest, James D. Journal of the American Chemical Society, 1981 , vol. 103, # 20 p. 6224 - 6226

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Citation Number: 33

Abstract

6 H, NCH, CH, SH HNO,+ this higher pH, nitroimidazole 1 is also consumed by direct hydrolysis, which accounts for the reduced yield of thioimidaz~ les.~~~ Assignment of structures 2 and 3 to the products is consistent with several observations. Reduction of both compounds in the presence of Raney nickel produced 2-methylimidazole-1-ethanol (4)'O.''and confirmed that the compounds were thioimidazoles. In addition, their'H NMR ...