Multiple-view diffuse optical tomography system based on time-domain compressive measurements

Andrea Farina, Marta Betcke, Laura di Sieno, Andrea Bassi, Nicolas Ducros, Antonio Pifferi, Gianluca Valentini, Simon Arridge, and Cosimo D’Andrea

Index: 10.1364/OL.42.002822

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Abstract

Compressive sensing is a powerful tool to efficiently acquire and reconstruct an image even in diffuse optical tomography (DOT) applications. In this work, a time-resolved DOT system based on structured light illumination, compressive detection, and multiple view acquisition has been proposed and experimentally validated on a biological tissue-mimicking phantom. The experimental scheme is based on two digital micromirror devices for illumination and detection modulation, in combination with a time-resolved single element detector. We fully validated the method and demonstrated both the imaging and tomographic capabilities of the system, providing state-of-the-art reconstruction quality.