An Efficient Synthesis of. BETA.-Aroylacrylic Acid Ethyl Ester by the Friedel-Crafts Reaction in the Presence of Diethyl Sulfate

K Onoue, T Shintou, CS Zhang, I Itoh

Index: Onoue, Ken-Ichi; Shintou, Taichi; Zhang, Chang Shan; Itoh, Isamu Chemistry Letters, 2006 , vol. 35, # 1 p. 22 - 23

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Citation Number: 10

Abstract

An β-Aroylacrylic acid ethyl ester such as ethyl (E)-4-(3, 4-dimethoxyphenyl)-4-oxo-2- butenoate (1) can be obtained in good yield and with excellent purity by way of the Friedel– Crafts reaction in which 1, 2-dimethoxybenzene (2) is treated with maleic anhydride (3) and aluminum chloride in the presence of diethyl sulfate (4) under mild conditions.