Rapid Ti (Oi-Pr) 4 facilitated synthesis of α, α, α-trisubstituted primary amines by the addition of Grignard reagents to nitriles under microwave heating conditions

R Wang, BT Gregg, W Zhang, KC Golden, JF Quinn…

Index: Wang, Ruifang; Gregg, Brian T.; Zhang, Wei; Golden, Kathryn C.; Quinn, John F.; Cui, Peng; Tymoshenko, Dmytro O. Tetrahedron Letters, 2009 , vol. 50, # 50 p. 7070 - 7073

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Citation Number: 7

Abstract

A series of carbinamines (α, α, α-trisubstituted amines) have been prepared in a simple and efficient one-pot procedure by the addition of Grignard reagents to a series of aliphatic, aromatic and heteroaromatic nitriles. The resulting magnesium imines are subsequently converted to the desired amine after treatment with Ti (Oi-Pr) 4 and additional microwave heating. Key to this procedure is the use of microwave heating for both steps of the ...