Enantioselective Hydrogenation of α??Dehydroamino Acid Esters Catalyzed by Rhodium Complexes with Chiral Bisaminophosphine Ligands

X Sun, W Li, L Zhou, X Zhang

Index: Sun, Xianfeng; Li, Wei; Zhou, Le; Zhang, Xumu Advanced Synthesis and Catalysis, 2010 , vol. 352, # 7 p. 1150 - 1154

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Citation Number: 6

Abstract

Abstract A highly efficient strategy for the synthesis of a series of chiral bisaminophosphine ligands was well established with several remarkable features. The synthetic utility of these ligands was explored for rhodium-catalyzed asymmetric hydrogenations of α-dehydroamino acid esters. Up to 98% ee values were achieved for the enantioselective synthesis of aminocarboxylic acids and their derivatives, which are very important chiral building ...