Enantioselective parallel synthesis using polymer-supported chiral Co (salen) complexes

S Peukert, EN Jacobsen

Index: Peukert, Stefan; Jacobsen, Eric N. Organic Letters, 1999 , vol. 1, # 8 p. 1245 - 1248

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Citation Number: 74

Abstract

The kinetic resolution of epoxides with phenols catalyzed by a polymer-supported Co (salen) complex is applied to the first enantioselective catalytic synthesis of parallel libraries. The corresponding 1-aryloxy-2-alcohols are obtained in high yield, purity, and enantiomeric excess. Further elaboration with diversity elements provides highly efficient access to important classes of pharmacologically active compounds.