Synthesis and cardiac electrophysiological activity of N-substituted-4-(1H-imidazol-1-yl) benzamides-new selective class III agents

…, WC Lumma Jr, K Nickisch, RA Wohl…

Index: Morgan, Thomas K.; Lis, Randall; Lumma, William C.; Nickisch, Klaus; Wohl, Ronald A.; et al. Journal of Medicinal Chemistry, 1990 , vol. 33, # 4 p. 1091 - 1097

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Citation Number: 52

Abstract

1 whether other functional groups could be used with N-substituted benzamides to give selective class I11 agents. In a series of 8-phenylimidazo [l, 2-a]-and-[1, 5-a] pyridines prepared as potential inotropic agents it was observed that substitution of the phenyl ring at the para position with a lH-imidazol-1-yl moiety (eg, 2 and 3) produced compounds with indications o1 class I11 electrop.. ysiological activity.% On the basis of this observation, ...