Organic letters

Suzuki–Miyaura cross-coupling of heteroaryl halides and arylboronic acids in continuous flow

T Noël, AJ Musacchio

Index: Noel, Timothy; Musacchio, Andrew J. Organic Letters, 2011 , vol. 13, # 19 p. 5180 - 5183

Full Text: HTML

Citation Number: 46

Abstract

General continuous-flow conditions for the Suzuki–Miyaura cross-coupling of heteroaryl halides and (hetero) arylboronic acids have been developed. A wide range of heterobiaryl products is obtained in excellent yields (20 examples) employing low catalyst loadings (0.05– 1.5 mol% Pd).

Related Articles:

A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives

[Maguire, Martin P.; Sheets, Kimberly R.; McVety, Karen; Spada, Alfred P.; Zilberstein, Asher Journal of Medicinal Chemistry, 1994 , vol. 37, # 14 p. 2129 - 2137]

Synthesis and reactivity of lithium tri (quinolinyl) magnesates

[Dumouchel, Sylvain; Mongin, Florence; Trecourt, Francois; Queguiner, Guy Tetrahedron, 2003 , vol. 59, # 43 p. 8629 - 8640]

One??pot preparation of unsymmetrical biaryls via Suzuki Cross??Coupling reaction of aryl halide using phase??transfer catalyst in a biphasic solvent system

[Miura, Masanori; Koike, Takanori; Ishihara, Tsukasa; Sakamoto, Shuichi; Okada, Minoru; Ohta, Mitsuaki; Tsukamoto, Shin-Ichi Synthetic Communications, 2007 , vol. 37, # 5 p. 667 - 674]

More Articles...