Pharmacokinetic evaluation of the anticancer prodrug simmitecan in different experimental animals

Z Hu, X Li, F Du, J Yang, W Niu, F Xu, F Wang…

Index: Hu, Zhe-Yi; Li, Xiu-Xue; Du, Fei-Fei; Yang, Jun-Ling; Niu, Wei; Xu, Fang; Wang, Feng-Qing; Li, Chuan; Sun, Yan Acta Pharmacologica Sinica, 2013 , vol. 34, # 11 p. 1437 - 1448

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Citation Number: 2

Abstract

Aim: To investigate the pharmacokinetics and disposition of simmitecan (LP) that was a water-soluble ester prodrug of chimmitecan (L-2-Z) with potent anti-tumor activities in different experimental animals, and to assess its drug-drug interaction potential. Methods: SD rats were injected with a single iv bolus doses of LP (3.75, 7.5 and 15 mg/kg). The pharmacokinetics, tissue distribution, excretion and metabolism of LP and its active ...