Design, synthesis and biological evaluation of small molecular polyphenols as entry inhibitors against H 5 N 1

J Yang, JX Yang, F Zhang, G Chen, W Pan, R Yu…

Index: Yang, Jian; Yang, Jing Xiang; Zhang, Fang; Chen, Gang; Pan, Wei; Yu, Rui; Wu, Shuwen; Tien, Po Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 12 p. 2680 - 2684

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Citation Number: 6

Abstract

Abstract To find novel compounds against H 5 N 1, three series of known or novel small molecular polyphenols were synthesized and tested in vitro for anti-H 5 N 1 activity. In addition, the preliminary structure–antiviral activity relationships were elaborated. The results showed that some small molecular polyphenols had better anti-H 5 N 1 activity, and could serve as novel virus entry inhibitors against H 5 N 1, likely targeting to HA2 protein. ...

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Design, synthesis and biological evaluation of small molecular polyphenols as entry inhibitors against H 5 N 1

Abstract

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