Design and synthesis of 1, 3-biarylsulfanyl derivatives as new anti-breast cancer agents

…, R Saxena, A Dwivedi, MI Siddiquee, U Siddiqui…

Index: Kumar, Atul; Tripathi, Vishwa Deepak; Kumar, Promod; Gupta, Lalit Prakash; Akanksha; Trivedi, Ritu; Bid, Hemant; Nayak; Siddiqui, Jawed A.; Chakravarti, Bandana; Saxena, Ruchi; Dwivedi, Anila; Siddiquee; Siddiqui; Konwar, Rituraj; Chattopadhyay, Naibedya Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 18 p. 5409 - 5419

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Citation Number: 13

Abstract

A new series of 1, 3-biarylsulfanyl derivatives (homodibenzyl core motif) have been designed and synthesized as new estrogen receptor ligands by chopping benzothiophene core of raloxifene to engender seco-raloxifene scaffold. All the synthesized compounds were screened for anti-proliferative, anti-osteoporotic, and anti-implantation activity. Compounds (35, 36) having basic amino anti-estrogenic side chain were exhibiting potential anti- ...

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