Fast and green one-pot multicomponent synthesis of a library of pyrrolo [1, 2-c] pyrimidines under microwave irradiation

E Georgescu, F Georgescu, C Draghici…

Index: Georgescu, Emilian; Georgescu, Florentina; Draghici, Constantin; Cristian, Liliana; Popa, Marcel Mirel; Dumitrascu, Florea Combinatorial Chemistry and High Throughput Screening, 2013 , vol. 16, # 10 p. 851 - 857

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Citation Number: 4

Abstract

A simple, clean and rapid one-pot three component, microwave-assisted synthesis of pyrrolo [1, 2-c] pyrimidine derivatives starting from various substituted pyrimidines, 2- bromoacetophenones and nonsymmetrical, electron deficient alkynes in 1, 2-epoxybutane which acts both as solvent and acid scavenger is reported. This one-pot three component synthesis implies short reaction times being at the same time highly cost-effective and ...