Synthesis and antimicrobial activities of new polyhalogenated benzimidazoles

AE Laudy, R Moo??Puc, R Cedillo??Rivera…

Index: Laudy, Agnieszka E.; Moo-Puc, Rosa; Cedillo-Rivera, Roberto; Kazimierczuk, Zygmunt; Orzeszko, Andrzej Journal of Heterocyclic Chemistry, 2012 , vol. 49, # 5 p. 1059 - 1065

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Citation Number: 2

Abstract

Abstract A series of new polyhalogenated benzimidazoles has been synthesized and their antibacterial and antiprotozoal activity was evaluated. Several of new substituted halogenobenzimidazoles and their 2′-deoxynucleosides showed noteworthy antiprotozoal toxicity particularly against Giardia lamblia. The most potent agents against bacteria and fungi were 4, 5, 6, 7-tetrachlorobenzimidazoles with polyfluoroalkyl chain at position 2 of ...