Tetrahedron Letters

Vasicine catalyzed direct C–H arylation of unactivated arenes: organocatalytic application of an abundant alkaloid

S Sharma, M Kumar, V Kumar, N Kumar

Index: Sharma, Sushila; Kumar, Manoranjan; Kumar, Vishal; Kumar, Neeraj Tetrahedron Letters, 2013 , vol. 54, # 36 p. 4868 - 4871

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Citation Number: 20

Abstract

Abstract Vasicine, a quinazoline alkaloid isolated from Adhatoda vasica, has been employed as an organocatalyst for direct C–H arylation of unactivated arenes with aryl iodides/bromides without the assistance of any transition metal catalyst. A number of sensitive functional groups such as methyl, methoxy, O-benzyl, acetyl, and amino were well tolerated under present reaction conditions. Mechanistic investigation supported the ...

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