Semisynthetic cephalosporines. The synthesis of some substituted tetrazolylacetic acids

Ľ Janda, Z Votický, J Světlík, J Grimová…

Index: Janda; Voticky; Svetlik; et al. Collection of Czechoslovak Chemical Communications, 1984 , vol. 49, # 6 p. 1505 - 1514

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Citation Number: 5

Abstract

Abstract 5-[5-(Substituted phenyl)-2-furyl]-1-tetrazolylacetic acids were synthesized from ethyl 5-(substituted phenyl)-2-furylcarbamidoacetates and phosphorus pentachloride via the corresponding imidoyl chlorides, which gave with sodium azide the respective ethyl 5-[5- (substituted phenyl)-2-furyl]-1-tetrazolyl acetates. A positive antiinflammatory effect was found when testing the acids obtained by hydrolysis of the acetates prepared.