Bulletin of the Chemical Society of Japan

Baker's Yeast Reduction of. ALPHA.-(Acylamino) acetophenones and Lipase Catalyzed Resolution of 2-Acylamino-1-arylethanols.

T Izumi, K Fukaya

Index: Izumi, Taeko; Fukaya, Katsumi Bulletin of the Chemical Society of Japan, 1993 , vol. 66, # 4 p. 1216 - 1221

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Citation Number: 23

Abstract

Enzymatic reduction of α-acylaminoacetophenones with fermenting baker's yeast afforded optically active (R)-2-acylamino-1-arylethanols. Furthermore, lipase-catalyzed resolution of the 2-acylamino-1-arylethanols using vinyl acetate as an acyl donor resulted in the formation of (S)-1-acetoxy-2-acylamino-1-arylethanols and (R)-2-acylamino-1-arylethanols.

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