Journal of Medicinal Chemistry

Monoamine Oxidase Inhibitors--I. 1-Alkyl and 1-Aralkyl-2-(picolinoyl and 5-methyl-3-isoxazolylcarbonyl) hydrazines

TS Gardner, E Wenis, J Lee

Index: Gardner,T.S. et al. Journal of Medicinal and Pharmaceutical Chemistry, 1960 , vol. 2, p. 133 - 145

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Citation Number: 18

Abstract

In the course of the clinical investigation of l-isopropyl-2-isonicotiiioylhydrazine (I),* a compound prepared by Fox1 of these laboratories in an antituberculosis drug programme, a marked central activity, manifested in improvement of appetite and attitude, was notede2 This led to the successful investigation of the compound in psychotic depression. 3 Further interest in the compound was stimulated by the reports of its pain-blocking effect in angina ...