In search of simplicity and flexibility: A rational access to twelve fluoroindolecarboxylic acids

M Schlosser, A Ginanneschi…

Index: Schlosser, Manfred; Ginanneschi, Assunta; Leroux, Frederic European Journal of Organic Chemistry, 2006 , # 13 p. 2956 - 2969

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Citation Number: 21

Abstract

Abstract All twelve indolecarboxylic acids 1–12 carrying both a fluorine substituent and a carboxy group at the benzo ring have been prepared either directly from the corresponding fluoroindoles 13–16 or from the chlorinated derivatives 22, 23 and 25 by hydrogen/metal permutation (“metalation”), or from the bromo-or iodofluoroindoles 17–20 and 26, 27, 29 and 30 by halogen/metal permutation, the organometallic intermediate being each time ...