Novel 3-carboxamide-coumarins as potent and selective FXIIa inhibitors

S Robert, C Bertolla, B Masereel…

Index: Robert, Severine; Bertolla, Carine; Masereel, Bernard; Dogne, Jean-Michel; Pochet, Lionel Journal of Medicinal Chemistry, 2008 , vol. 51, # 11 p. 3077 - 3080

Full Text: HTML

Citation Number: 50

Abstract

Recently, FXIIa was highlighted as an original attractive target for the development of new anticoagulant drugs with low rates of therapy-related hemorrhages. In this work, we describe the development of a new series of 3-carboxamide-coumarins that are the first potent and selective nonpeptidic inhibitors of FXIIa.

Related Articles:

Montmorillonite KSF as an inorganic, water stable, and reusable catalyst for the Knoevenagel synthesis of coumarin-3-carboxylic acids

[Bigi, Franca; Chesini, Luca; Maggi, Raimondo; Sartori, Giovanni Journal of Organic Chemistry, 1999 , vol. 64, # 3 p. 1033 - 1035]

Room Temperature One-Pot Green Synthesis of Coumarin-3-carboxylic Acids in Water: A Practical Method for the Large-Scale Synthesis

[Undale, Kedar A.; Gaikwad, Dipak S.; Shaikh, Tarannum S.; Desai, Uday V.; Pore, Dattaprasad M. Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2012 , vol. 51, # 7 p. 1039 - 1042]

More Articles...