Synthesis, characterization and molecular docking studies of some new 1, 3, 4-oxadiazolines bearing 6-methylpyridine moiety for antimicrobial property

PC Shyma, B Kalluraya, SK Peethambar…

Index: Shyma; Kalluraya, Balakrishna; Peethambar; Telkar, Sandeep; Arulmoli European Journal of Medicinal Chemistry, 2013 , vol. 68, p. 394 - 404

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Citation Number: 17

Abstract

Abstract A new series of 3-acetyl-2-aryl-2H/methyl-5-[3-(6-methylpyridinyl)]-2, 3-dihydro-[1, 3, 4]-oxadiazole derivatives were synthesized from 6-methyl nicotinate through a multistep reaction sequence. The structures of newly synthesized compounds were established on the basis of elemental analysis, IR, 1 H NMR, 13 C NMR and mass spectral data. Three dimensional structure of the compound 5f was further confirmed by single crystal X-ray ...