Synthesis of tacrine derivatives under solventless conditions

MA Khalilzadeh, A Hosseini…

Index: Khalilzadeh, Mohammad A.; Hosseini, Abolfazl; Tajbakhsh', Mahmoud Journal of Heterocyclic Chemistry, 2007 , vol. 44, # 3 p. 535 - 538

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Citation Number: 10

Abstract

Dementia is the most common psychiatric disorder of old age, and Alzheimer's disease [1] is its most common cause. Alzheimer's disease involves the degeneration of cholinergic neurones in the cerebral cortex and hippocampus, areas of the brain particularly associated with memory, higher intellectual functioning, and consciousness [2]. The biochemical deficits also extend into other neurochemical systems, affecting the levels of monoamine ...