Structure-antigastrin activity relationships of new (R)-4-benzamido-5-oxopentanoic acid derivatives

F Makovec, W Peris, L Revel, R Giovanetti…

Index: Makovec, Francesco; Peris, Walter; Revel, Laura; Giovanetti, Roberto; Mennuni, Laura; Rovati, Lucio C. Journal of Medicinal Chemistry, 1992 , vol. 35, # 1 p. 28 - 38

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Citation Number: 52

Abstract

New (R)-Cbenzamid~ 50xopentanoic acid derivatives were synthesized by a stereoconservative procedure and evaluated in vitro for their capacity to inhibit the binding of [1251](BH)-CCK-8 to either rat peripheral (CCK-A) or central (CCK-B) CCK receptors, or the binding of [3H] pentagastrin to rabbit gastric glands, as well as to inhibit, in vivo, the acid secretion induced by pentagastrin infusion in the perfused rat stomach. The parent ...