A new convergent synthesis of WS-5995-B, an anticoccidial antibiotic from Streptomyces auranticolor

DA Rama, DS Iyengar, M Pardhasaradhi

Index: Rama Devi; Iyengar; Pardhasaradhi Tetrahedron, 1994 , vol. 50, # 8 p. 2543 - 2550

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Citation Number: 3

Abstract

A new synthesis of WS-5995-B, an anticoccidial antibiotic isolated from Streptomyces auranticolor is reported via the coupling reaction between 3-bromo-5, 6, 7, 8- tetrahydrojuglone, and 3-methoxy-5-methyl anthranilic acid. A simple method for the preparation of the anthranilate 7 starting from p-toluidine by shorter sequence is reported.