Synthesis and pharmacological screening of 1??chloro??3??(2??propynyloxy)??2??propanols and 2??[(2??propynyloxy) methyl] oxiranes

RB Fugitt, GS Wu, LC Martinelli

Index: Fugitt; Wu; Martinelli Journal of Pharmaceutical Sciences, 1973 , vol. 62, # 11 p. 1894 - 1896

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Abstract

Abstract Some researchers have found that an ethynyl group is essential for optimal anticancer activity of carbamate esters. In addition, it has been observed that bisepoxides are generally more potent anticancer agents than monoepoxides. These observations led to