2-Phenylpyrroles as conformationally restricted benzamide analogs. A new class of potential antipsychotics. 2

I Van Wijngaarden, CG Kruse…

Index: Wijngaarden, Ineke van; Kruse, Chris G.; Heyden, Jan A. M. van der; Tulp, Martin Th. M. Journal of Medicinal Chemistry, 1988 , vol. 31, # 10 p. 1934 - 1940

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Citation Number: 41

Abstract

A series of 2-phenylpyrrole Mannich bases was synthesized and screened in pharmacological models for antipsychotic activity and extrapyramidal effects. Structure modifications of 5-(4-fluorophenyl)-2-[[4-(2-methoxyphenyl)-l-piperazinyl] methyl] pyrrole (l), the prototype of a new class of sodium-independent atypical dopamine D-2 antagonists, resulted in 2-[[4-(7-benzofuranyl)-l-piperazinyl] methyl]-5-(4-fluorophenyl) pyrrole (15), ...