Furocoumarin Studies. Synthesis of Psoralene and Related Furocoumarins1

EC Horning, DB Reisner

Index: Horning; Reisner Journal of the American Chemical Society, 1950 , vol. 72, p. 1514,1516

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Citation Number: 30

Abstract

(VII) was prepared from XI in% yo yield by condensation of the aldehyde with malonic acid according to the method of Adams and Mathieu. 6 Preliminary attempts to prepare VI1 by the Doebner procedure were unsuccessful and XI was recovered unchanged. A review of reactions of this type appearing in the literature4s6-6 indicated that the Knoevenagel and Doebner methods are often unsatisfactory when applied to 0-or p-hydrox ybenzaldehydes.