C1'-cycloalkyl side chain pharmacophore in tetrahydrocannabinols

DP Papahatjis, VR Nahmias, SP Nikas…

Index: Tsotinis, Andrew; Vlachou, Margarita; Papahatjis, Demetris P.; Calogeropoulou, Theodora; Nikas, Spyros P.; Garratt, Peter J.; Piccio, Vincent; Vonhoff, Stefan; Davidson, Kathryn; Teh, Muy-Teck; Sugden, David Journal of Medicinal Chemistry, 2006 , vol. 49, # 12 p. 3509 - 3519

Full Text: HTML

Citation Number: 30

Abstract

In earlier work we have provided evidence for the presence of a subsite within the CB1 and CB2 cannabinoid receptor binding domains of classical cannabinoids. This putative subsite corresponds to substituents on the C1'-position of the C3-alkyl side chain, a key pharmacophoric feature in this class of compounds. We have now refined this work through the synthesis of additional C1'-cycloalkyl compounds using newly developed approaches. ...

Related Articles:

Novel tetrahydro-β-carboline-1-carboxylic acids as inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2)

[Trujillo, John I.; Meyers, Marvin J.; Anderson, David R.; Hegde, Shridhar; Mahoney, Matthew W.; Vernier, William F.; Buchler, Ingrid P.; Wu, Kun K.; Yang, Syaluan; Hartmann, Susan J.; Reitz, David B. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 16 p. 4657 - 4663]

More Articles...