The Journal of Organic Chemistry

Carboxyalthioacrylates

PD Halphen, TC Owen

Index: Halphen,P.D.; Owen,T.C. Journal of Organic Chemistry, 1973 , vol. 38, # 20 p. 3507 - 3510

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Citation Number: 26

Abstract

I I1 I11 suitably constructed thioacrylates might well be useful intermediates in the synthesis of such fused P-lactam antibiotics, the group X providing the nitrogen atom, and either X or the thioacrylate function the carbonyl group. Thioacrylates, moreover, are conveniently prepared in either the cis or the trans geometry, and preservation of this geometry during cyclization might permit a stereoselective penicillin-cephalosporin synthesis.