Selective non zinc binding inhibitors of MMP13

…, G Karoutchi, N Rankine, G Hamlin, PA MacFaul…

Index: Savi, Chris De; Morley, Andrew D.; Ting, Attilla; Nash, Ian; Karabelas, Kostas; Wood, Christine M.; James, Michael; Norris, Stephen J.; Karoutchi, Galith; Rankine, Neil; Hamlin, Gordon; MacFaul, Philip A.; Ryan, David; Baker, Sarah V.; Hargreaves, David; Gerhardt, Stefan Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 14 p. 4215 - 4219

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Citation Number: 16

Abstract

Abstract Directed screening has identified a novel series of MMP13 inhibitors that possess good levels of activity whilst possessing excellent selectivity over related MMPs. The binding mode of the series has been solved by co-crystallisation and demonstrates an interesting mode of inhibition without interaction with the catalytic zinc atom.