A highly chemoselective Boc protection of amines using sulfonic-acid-functionalized silica as an efficient heterogeneous recyclable catalyst

B Das, K Venkateswarlu, M Krishnaiah, H Holla

Index: Das, Biswanath; Venkateswarlu, Katta; Krishnaiah, Maddeboina; Holla, Harish Tetrahedron Letters, 2006 , vol. 47, # 43 p. 7551 - 7556

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Citation Number: 60

Abstract

A facile and versatile method for the chemoselective Boc protection of amines has been developed by a treatment with (Boc) 2O in the presence of sulfonic-acid-functionalized silica as a catalyst. The method is general for the preparation of N-Boc derivatives of aliphatic (acyclic and cyclic), aromatic, and heteroaromatic amines; primary and secondary amines; aminols, amino-esters; and sulfonamides. The catalyst works under heterogeneous ...