Synthesis and in vitro antitumor activities of novel 4-anilinoquinazoline derivatives

V Chandregowda, AK Kush, GC Reddy

Index: Chandregowda, Venkateshappa; Kush; Chandrasekara Reddy European Journal of Medicinal Chemistry, 2009 , vol. 44, # 7 p. 3046 - 3055

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Citation Number: 78

Abstract

A series of 6, 7-dialkoxy-4-anilinoquinazolines were designed, synthesized by substituting different heterocycles on 6-position and a variety of anilines on 4-position of the quinazoline. These novel quinazoline compounds were screened for their cytotoxic effect on epidermal growth factor receptor overexpressing skin epidermoid carcinoma cell line (A431), by using nonoverexpressing tumor cells as negative control (breast adeno carcinoma cell line MCF ...

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