Tetrahedron Letters

Polymethylhydrosiloxane (PMHS)/trifluoroacetic acid (TFA): a novel system for reductive amination reactions

JP Patel, AH Li, H Dong, VL Korlipara, MJ Mulvihill

Index: Patel, Jay P.; Li, An-Hu; Dong, Hanqing; Korlipara, Vijaya L.; Mulvihill, Mark J. Tetrahedron Letters, 2009 , vol. 50, # 44 p. 5975 - 5977

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Citation Number: 26

Abstract

Polymethylhydrosiloxane (PMHS)/trifluoroacetic acid (TFA) was discovered as a novel metal- free system for reductive amination reactions. A variety of (het) aryl amines as well as a representative carbamate and urea were successfully alkylated by benzaldehyde in the presence of PMHS and TFA in dichloromethane at room temperature in moderate to excellent yields (28–87%). Furthermore, this reaction protocol was successfully applied to ...

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