… conformationally restricted oxazolidinones possessing Gram-positive and fastidious Gram-negative antibacterial activity. Part 2: Amino substitutions on heterocyclic D- …

AL Choy, JVNV Prasad, FE Boyer, MD Huband…

Index: Choy, Allison L.; Vara Prasad; Boyer, Frederick E.; Huband, Michael D.; Dermyer, Michael R. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 16 p. 4699 - 4702

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Citation Number: 11

Abstract

A novel series of conformationally restricted oxazolidinones was synthesized, in which the heterocyclic D ring was substituted with various amino groups. Several analogs exhibited potent activity against both Gram-positive and fastidious Gram-negative organisms. Certain amino-substituted analogs also exhibited improved aqueous solubility compared to the corresponding un-substituted heterocyclic D-ring analogs.

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