Process research and development for the kilogram manufacture of the SRC kinase inhibitor AZD0530

JG Ford, SM Pointon, L Powell…

Index: Organic Process Research and Development, , vol. 14, # 5 p. 1078 - 1087

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Citation Number: 9

Abstract

... Organic Process Research & Development. ... One final note of caution with this process was the detection of ppm quantities of hydrogen cyanide in the off gases ... Conversion of 15 to isatin 16 was also examined by using the reported procedure for isatin.(3) Following the literature ...