Synthesis of Substances Related to Fluticasone Propionate

J Zheng, Q Lai, Y Dai, Q Zhao…

Index: Zheng, Jin; Lai, Qinglin; Dai, Yiru; Zhao, Qingjie; Shen, Jingshan Organic Preparations and Procedures International, 2008 , vol. 40, # 6 p. 566 - 566

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Abstract

Impurity 5 is a new compound isolated during our process optimization. Impurity 9 had been synthesized6 in 22% yield from 1 as a biologically active compound used to treat allergy and immunoinflammatory disorde $*'and compound 11 has been suggested as another possible impurity?." However, as far as we know no synthetic details and spectral data of these three compounds related to fluticasone propionate (5, 9 and ll) s have been described and now ...