Use of activated enol ethers in the synthesis of pyrazoles: reactions with hydrazine and a study of pyrazole tautomerism

…, M Breza, M Fronc, W Holzer, V Milata

Index: Tarabova, Denisa; Soralova, Stanislava; Breza, Martin; Fronc, Marek; Holzer, Wolfgang; Milata, Viktor Beilstein Journal of Organic Chemistry, 2014 , vol. 10, p. 752 - 760

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Citation Number: 7

Abstract

Abstract Activated enol ethers derived from esters or the dinitrile of malonic acid, or from pentane-2, 4-dione were treated with hydrazine hydrate. The structures of the obtained products–pyrazoles 5–were studied with a focus on tautomerism and supramolecular structure. A reverse addition of the reagents led to the isolation of two novel products, namely bis-enehydrazines 6 with an unsymmetrical arrangement of the formally ...

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