A new 5-HT3 receptor ligand. II. Structure-activity analysis of 5-HT3 receptor agonist action in the gut.

…, Y Sato, K Kobayashi, F KONNO, T SONEDA…

Index: Yamada, Megumi; Sato, Yasuo; Kobayashi, Kazuko; Konno, Fukio; Soneda, Tomoko; Watanabe, Takashi Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 3 p. 445 - 451

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Citation Number: 20

Abstract

Several modified 2-piperazinyl benzoxazole derivatives, which exhibit an agonistic effect on gastrointestinal motility, were synthesized and their effects on the contraction of guinea-pig ileum were examined. The quaternary piperazinyl benzoxazole structure has a restricted conformation and stereostructure compared to those of the other 5-HT 3 receptor agonists, serotonin and meta-chlorophenylbiguanide. The mutual positions of the aromatic ring, ...