Synthesis of Botryllamides and Lansiumamides via Ruthenium-Catalyzed Hydroamidation of Alkynes
LJ Goossen, M Blanchot, M Arndt, KSM Salih
Index: Goossen, Lukas J.; Blanchot, Mathieu; Arndt, Matthias; Salih, Kifah S. M. Synlett, 2010 , # 11 p. 1685 - 1687
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Abstract
Abstract Ruthenium-catalyzed hydroamidations of alkynes allow a concise synthetic entry to both E-and Z-configured enamide natural products. This was demonstrated by the synthesis of botryllamides C and E, lansiumamides A and B, and lansamide I in 1-3 steps and 57-98% yield from simple, commercially available precursors.
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