anti-Sulfonamide antibodies catalyse the hydrolysis of a heterocyclic amide

…, A Colombatti, C Ebert, P Linda, F Tonizzo

Index: Benedetti, Fabio; Berti, Federico; Colombatti, Alfonso; Ebert, Cynthia; Linda, Paolo; Tonizzo, Federico Chemical Communications, 1996 , # 12 p. 1417 - 1418

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Citation Number: 11

Abstract

Hydrolysis of the amide bond is a major target of research in catalytic antibodies. This approach could be of use in the design of catalysts for sequence specific peptide hydrolysis; however, amide hydrolysing antibodies are still rare in spite of many efforts. So far, the only successful approach to amidase-like antibodies has been based on the use of phosphinate or phosphonate esters' and amides2 as haptenic transition state analogues (TSA). In contrast, ...

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