Efficient synthesis of non-K-region trans-dihydrodiols of polycyclic aromatic hydrocarbons from o-quinones and catechols
KL Platt, F Oesch
Index: Platt, Karl L.; Oesch, Franz Journal of Organic Chemistry, 1983 , vol. 48, # 2 p. 265 - 268
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Citation Number: 106
Abstract
Non-K-region'dihydro diols of polycyclic aromatic hydrocarbons (PAH), generated by the epoxide hydrolase mediated hydration of metabolically formed arene oxides, play an important role in the metabolism of PAH. 2-7 They are precursors of dihydro diol epoxides, some of which are considered to be ultimate carcinogenic metabolites of PAH. &'O
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