Biologically active dihydrodiol metabolites of polycyclic aromatic hydrocarbons structurally related to the potent carcinogenic hydrocarbon 7, 12-dimethylbenz [a] …

…, C Cortez, T Sugiyama, Y Ito, TW Sawyer…

Index: Harvey; Cortez; Sugiyama; Ito; Sawyer; DiGiovanni Journal of Medicinal Chemistry, 1988 , vol. 31, # 1 p. 154 - 159

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Citation Number: 27

Abstract

Syntheses of the trans-dihydrodiol derivatives implicated as the proximate carcinogenic metabolites of the polycyclic hydrocarbons cholanthrene, 6-methylcholanthrene, benz [a] anthracene, and 7-and 12-methylbenz [a] anthracene are described. These compounds are useful models for research to determine the molecular basis of the strong enhancement of carcinogenicity consequent upon methyl substitution in nonbenzo bay molecular sites and ...