Synthesis of biologically active metabolites of 7-methylbenz [a] anthracene
HM Lee, RG Harvey
Index: Lee,H.M.; Harvey,H.R. Journal of Organic Chemistry, 1979 , vol. 44, p. 4948 - 4953
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Citation Number: 21
Abstract
Syntheses are described of the trans 3, 4-dihydro diol (la) and the corresponding anti diol epoxide (2) of 7-methylbenz [alanthracene, implicated as proximate and ultimate carcinogenic metabolites, respectively, of this potent precarcinogen. Additional syntheses are reported of the related trans 1, Zdihydro diol (3a), the corresponding anti and syn diol epoxides, and 2-and 3-hydroxy-7-methylbenz [a] anthracene, additional potential ...
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