Synthesis and evaluation of 3-substituted analogs of 1, 2, 3, 4-tetrahydroisoquinoline as inhibitors of phenylethanolamine N-methyltransferase

GL Grunewald, DJ Sall, JA Monn

Index: Grunewald, Gary L.; Sall, Daniel J.; Monn, James A. Journal of Medicinal Chemistry, 1988 , vol. 31, # 4 p. 824 - 830

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Citation Number: 43

Abstract

Figure 1. The terminal step in epinephrine (Epi) biosynthesis catalyzed by phenylethanolamine N-methyltransferase (PNMT, EC 2.1. 1.28), which facilitates the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to the primary amine in norepinephrine (NE). S-Adenosyl-L-homocysteine is also formed through this process.