Synthesis and structure-activity relationships of CP-122,721, a second-generation NK-1 receptor antagonist

…, Y Gohda, M Tsuchiya, A Nagahisa, M Nakane…

Index: Rosen, Terry J.; Coffman, Karen J.; McLean, Stafford; Crawford, Rosemary T.; Bryce, Dianne K.; Gohda, Yoshiko; Tsuchiya, Megumi; Nagahisa, Atsushi; Nakane, Masami; Lowe III, John A. Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 3 p. 281 - 284

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Citation Number: 41

Abstract

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... The synthesis and SAR of benzylamine side chain analogs of the NK-1 receptor antagonist CP-99,994 are described. The 5-trifluoromethoxy analog, CP-122,721, shows superior in vivo blockade of NK-1 receptor mediated responses. ... The synthesis and SAR of ...

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